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Comparison between Dexmedetomidine and Midazolam as an Adjuvant to Lidocaine in Intravenous Regional Anesthesia for below Elbow Surgeries. Tarek E. Hassan* Adel R. Botros Yaser M. Nasr Anesthesia Surgical Intensive care department Faculty of Medicine Zagazig University Egypt. ABSTRACT
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Quality of anesthesia sensory and motor block characteristics duration of effective analgesia and incidence of side effects were compared. Results: The time for the first analgesic request was 320.80 ± 41.75 min in the dexmedetomidine group as compared to the morphine group (451.63 ± 38.55 min) P = 0.000.
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Apr 20 2017· The meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 11 All relevant references that compared the effect of DEX versus MDZ in paediatric anaesthesia with sevoflurane were identified. PubMed Ovid Web of Science and Public Health Management Corporation …
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For their sedative analgesic perioperative sympatholytic and cardiovascular stabilizing effects with reduced anesthetic requirements α-2 adrenergic receptor agonists such as more potent and highly selective dexmedetomidine have been the focus of interest for regional anesthesia. Intravenous dexmedetomidine infusion resulted in
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09.00 Lieselot Geerts Ghent University Hospital Impact of opioid free Anesthesia versus opioid Anesthesia on post-operative 11.50 Nina D''hondt UZ Leuven Systemic clonidine as an adjuvant for postoperative analgesia in ambulatory surgery : a 11.35 Michiel Denis Antwerp Intranasal dexmedetomidine to facilitate mask induction and prevent
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The clinical trial 8 was investigator-initiated multicenter randomized prospective parallel-group and single-blind conducted in 10 centers in France with an independent data and safety monitoring board to oversee the conduct and review safety data. Patients undergoing major noncardiac surgery received intraoperative balanced anesthesia featuring opioids …
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15. Bakan M Umutoglu T Topuz U et al. Opioid-free total intravenous anesthesia with propofol dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective randomized double-blinded study. Rev Bras Anestesiol. 2015:65(3):191-199. 16.
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AN OPIOID-FREE ANESTHETIC PRESCRIPTION. Based on evidence of drug action and interaction an opioid-free anesthetic can be delivered with infusions of lidocaine (0.03 mg/kg/min) dexmedetomidine (0.5 mcg/kg/hr) and 0.5 MAC isoflurane. For procedures of less than 2 hours’ duration a bolus dose of lidocaine and dexmedetomidine can be considered.
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Nov 05 2020· Yet dexmedetomidine impairs the thalamo-cortical functional connectivity mostly expressed as spindle waves (12–16 Hz) in the frontal area. 9 The matter is extremely complex as alterations in connectivity within distinct brain regions lead to different depths of anesthesia. Thus changes in thalamic-cortical connectivity lead to the
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For their sedative analgesic perioperative sympatholytic and cardiovascular stabilizing effects with reduced anesthetic requirements α-2 adrenergic receptor agonists such as more potent and highly selective dexmedetomidine have been the focus of interest for regional anesthesia. Intravenous dexmedetomidine infusion resulted in
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Anesthesia was maintained using propofol at 3-12 mg/kg/h and remifentanil at 0.01-0.2 μg/kg/min in Remifentanil group or dexmedetomidine at 0.01-0.02 μg/kg/min in Dexmedetomidine group keeping
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insertion and dexmedetomidine not used as treatment. Results: The evidence search and screening resulted in 15 RCTs. Eleven studies demonstrated dexmedetomidine is a superior adjuvant in preserving respirations and a stable hemodynamic profile. Four studies demonstrated dexmedetomidine could reduce propofol dose requirements by as much as 38%.
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Aug 21 2021· 3.1 Ketamine- and opioid-free anesthesia Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist with both central and peripheral analgesic effects that has been used as intrathecal adjuvant to local anesthetic due to its sedative and analgesic effects contributing to the maintenance of hemodynamic stability and minimizing stress
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using dexmedetomidine as an adjuvant to decrease the requirement of propofol and maintain stable hemodynamics intraoperatively. At the end of the educational tool feedback will also demonstrate if the information provided will improve anesthesia providers'' knowledge. Protection of Human Subjects
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Introduction. Dexmedetomidine (DEX) a highly selective alpha-2 receptor agonist has sedative analgesic and anti-anxiety effects during anesthesia [] via various mechanisms including perineural [2 3] intra-articular [4 5] and systemic administration [].As a new adjuvant to nerve block the perineural route for DEX can provide advantages in prolonged analgesia and …
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Introduction. Dexmedetomidine (DEX) a highly selective alpha-2 receptor agonist has sedative analgesic and anti-anxiety effects during anesthesia [] via various mechanisms including perineural [2 3] intra-articular [4 5] and systemic administration [].As a new adjuvant to nerve block the perineural route for DEX can provide advantages in prolonged analgesia and …
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Jul 01 2015· Dexmedetomidine a highly selective [[alpha].sub.2]-adrenergic agonist has analgesic sedative and anesthetic-sparing effects when used in systemic route. (25) Use of dexmedetomidine as an adjuvant mixed with local anesthetics has been performed with neuraxial anesthesia in both adult and pediatric patients. (1726)
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Dexmedetomidine is a potent α 2-adrenoceptors agonist and presynaptic activation of α 2-adrenoceptors in the locus ceruleus is responsible for both analgesic and sedative effect. 3 26 Therefore dexmedetomidine may be an effective adjuvant during general anesthesia by decreasing the doses of anesthetics and analgesics. 27-29 The primary end
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increase anesthesia and analgesia. It has improved spinal anesthesia and reduced the anesthetic drug related side effects including pruritus nausea and vomiting [8]. Dexmedetomidine and fentanyl have been used as adjuvant to local anesthetics in different surgeries to provide superior analgesia and to improve the dur-ation of the block [9–11].
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Quality of anesthesia sensory and motor block characteristics duration of effective analgesia and incidence of side effects were compared. Results: The time for the first analgesic request was 320.80 ± 41.75 min in the dexmedetomidine group as compared to the morphine group (451.63 ± 38.55 min) P = 0.000.
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